Role for the cholecystokinin-A receptor in fever: a study of a mutant rat strain and a pharmacological analysis.

@article{Ivanov2003RoleFT,
  title={Role for the cholecystokinin-A receptor in fever: a study of a mutant rat strain and a pharmacological analysis.},
  author={Andrei I. Ivanov and Vladimir A. Kulchitsky and Andrej A. Romanovsky},
  journal={The Journal of physiology},
  year={2003},
  volume={547 Pt 3},
  pages={941-9}
}
The involvement of the cholecystokinin (CCK)-A receptor in fever was studied. The polyphasic febrile responses to lipopolysaccharide (LPS; 10 microg kg-1, I.V.) were compared between wild-type Long-Evans (LE) rats and the CCK-A-receptor-deficient Otsuka LE Tokushima Fatty (OLETF) rats. The response of the wild-type rats was biphasic, which is typical for LE rats. Phases 1 and 2 of the response of the OLETF rats were similar to those of the LE rats, but the OLETF rats also developed a robust… CONTINUE READING
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