Role for the chlamydial type III secretion apparatus in host cytokine expression.

@article{Prantner2009RoleFT,
  title={Role for the chlamydial type III secretion apparatus in host cytokine expression.},
  author={Daniel Prantner and Uma M. Nagarajan},
  journal={Infection and immunity},
  year={2009},
  volume={77 1},
  pages={76-84}
}
In many important human pathogens, such as Shigella and Salmonella spp., the bacterial type III secretion (T3S) apparatus is required to initiate inflammation via activation of caspase-1- or NF-kappaB-dependent genes. Using an ex vivo infection model, the goal of the present study was to determine whether the chlamydial T3S apparatus also modulates the host inflammatory response. Infections of mouse peritoneal macrophages were performed with Chlamydia muridarum, and the expression of… CONTINUE READING
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