Role for the Ssu72 C-terminal domain phosphatase in RNA polymerase II transcription elongation.

@article{ReyesReyes2007RoleFT,
  title={Role for the Ssu72 C-terminal domain phosphatase in RNA polymerase II transcription elongation.},
  author={Mariela Reyes-Reyes and Michael Hampsey},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 3},
  pages={926-36}
}
The RNA polymerase II (RNAP II) transcription cycle is accompanied by changes in the phosphorylation status of the C-terminal domain (CTD), a reiterated heptapeptide sequence (Y(1)S(2)P(3)T(4)S(5)P(6)S(7)) present at the C terminus of the largest RNAP II subunit. One of the enzymes involved in this process is Ssu72, a CTD phosphatase with specificity for serine-5-P. Here we report that the ssu72-2-encoded Ssu72-R129A protein is catalytically impaired in vitro and that the ssu72-2 mutant… CONTINUE READING

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