Role for the Mammalian Swi5-Sfr1 Complex in DNA Strand Break Repair through Homologous Recombination

@inproceedings{Akamatsu2010RoleFT,
  title={Role for the Mammalian Swi5-Sfr1 Complex in DNA Strand Break Repair through Homologous Recombination},
  author={Yufuko Akamatsu and Maria Jasin},
  booktitle={PLoS genetics},
  year={2010}
}
In fission yeast, the Swi5-Sfr1 complex plays an important role in homologous recombination (HR), a pathway crucial for the maintenance of genomic integrity. Here we identify and characterize mammalian Swi5 and Sfr1 homologues. Mouse Swi5 and Sfr1 are nuclear proteins that form a complex in vivo and in vitro. Swi5 interacts in vitro with Rad51, the DNA strand-exchange protein which functions during HR. By generating Swi5(-/-) and Sfr1(-/-) embryonic stem cell lines, we found that both proteins… CONTINUE READING