• Medicine
  • Published in Circulation 2004

Role for the Kunitz-3 domain of tissue factor pathway inhibitor-alpha in cell surface binding.

@article{Piro2004RoleFT,
  title={Role for the Kunitz-3 domain of tissue factor pathway inhibitor-alpha in cell surface binding.},
  author={Orlando Piro and George J. Broze},
  journal={Circulation},
  year={2004},
  volume={110 23},
  pages={
          3567-72
        }
}
BACKGROUND Tissue factor pathway inhibitor (TFPI)-alpha, a key regulator of tissue factor-induced coagulation, contains 3 tandem Kunitz-type inhibitory domains. Kunitz-1 binds and inhibits factor VIIa in the factor VIIa/tissue factor complex, and Kunitz-2 binds and inhibits factor Xa. The role of the Kunitz-3 domain of TFPI-alpha, however, has remained an enigma. METHODS AND RESULTS To determine the structures within TFPI-alpha involved in its binding to cell surface, altered forms of TFPI… CONTINUE READING

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Tissue factor pathway inhibitor: structure-function.

  • Frontiers in bioscience
  • 2012
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