Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy.

@article{Haas2002RoleFR,
  title={Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy.},
  author={Carola A Haas and O. Dudeck and Matthias Kirsch and Csaba Huszka and Gunda Kann and Stefan Pollak and J. Zentner and Michael Frotscher},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 14},
  pages={5797-802}
}
The reelin signaling pathway plays a crucial role during the development of laminated structures in the mammalian brain. Reelin, which is synthesized and secreted by Cajal-Retzius cells in the marginal zone of the neocortex and hippocampus, is proposed to act as a stop signal for migrating neurons. Here we show that a decreased expression of reelin mRNA by hippocampal Cajal-Retzius cells correlates with the extent of migration defects in the dentate gyrus of patients with temporal lobe epilepsy… CONTINUE READING