Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells

@article{Brown1995RoleFP,
  title={Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells},
  author={WilliamJ. Brown and Daryll B. Dewald and Scott D Emr and Helen Plutner and William Edward Balch},
  journal={The Journal of Cell Biology},
  year={1995},
  volume={130},
  pages={781 - 796}
}
Previous work with the yeast Saccharomyces cerevisiae has demonstrated a role for a phosphatidylinositol-specific PI 3-kinase, the product of the VPS34 gene, in the targeting of newly synthesized proteins to the vacuole, an organelle functionally equivalent to mammalian lysosomes (Schu, P. V., K. Takegawa, M. J. Fry, J. H. Stack, M. D. Waterfield, and S. D. Emr. 1993. Science [Wash. DC]. 260:88-91). The activity of Vps34p kinase is significantly reduced by the PI 3-kinase inhibitors wortmannin… CONTINUE READING

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Vps34p is a phosphatidylinositol-specific PI 3-kinase required for vacuolar protein sorting in yeast and possesses both lipid and protein kinase activities• Z BioL Chem

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