Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction.

Abstract

Recently, the mitochondria have become the focus of attention as the site of O2 sensing underlying hypoxic pulmonary vasoconstriction (HPV). From a teleological standpoint, it is reasonable that the organelle where most of the cellular O2 is consumed would also be the site of O2 sensing. Originally, it was proposed that a drop in pO2 decreases the rate of… (More)

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