Role for mitochondrial reactive oxygen species in brain lipid sensing: redox regulation of food intake.

@article{Bnani2007RoleFM,
  title={Role for mitochondrial reactive oxygen species in brain lipid sensing: redox regulation of food intake.},
  author={Alexandre B{\'e}nani and St{\'e}phanie Troy and Mar{\'i}a del Carmen Barrag{\'a}n Carmona and Xavier Fioramonti and Anne Lorsignol and Corinne Leloup and Louis Casteilla and Luc P{\'e}nicaud},
  journal={Diabetes},
  year={2007},
  volume={56 1},
  pages={152-60}
}
The ability for the brain to sense peripheral fuel availability is mainly accomplished within the hypothalamus, which detects ongoing systemic nutrients and adjusts food intake and peripheral metabolism as needed. Here, we hypothesized that mitochondrial reactive oxygen species (ROS) could trigger sensing of nutrients within the hypothalamus. For this purpose, we induced acute hypertriglyceridemia in rats and examined the function of mitochondria in the hypothalamus. Hypertriglyceridemia led to… CONTINUE READING