Role for microglia in sex differences after ischemic stroke: importance of M2

@article{Bodhankar2015RoleFM,
  title={Role for microglia in sex differences after ischemic stroke: importance of M2},
  author={Sheetal Bodhankar and Andrew S. Lapato and Yingxin Chen and Arthur A. Vandenbark and Julie A Saugstad and Halina Offner},
  journal={Metabolic Brain Disease},
  year={2015},
  volume={30},
  pages={1515-1529}
}
Inflammation plays a critical role in the pathogenesis of ischemic stroke. This process depends, in part, upon proinflammatory factors released by activated resident central nervous system (CNS) microglia (MG). Previous studies demonstrated that transfer of IL-10+ B-cells reduced infarct volumes in male C57BL/6 J recipient mice when given 24 h prior to or therapeutically at 4 or 24 h after experimental stroke induced by 60 min middle cerebral artery occlusion (MCAO). The present study assesses… CONTINUE READING

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