Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome.

@article{Ichikawa1983RoleFI,
  title={Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome.},
  author={Iekuni Ichikawa and Helmut G. Rennke and John R. Hoyer and Kamal F. Badr and Nestor Schor and Julia L. Troy and Claude P. Lechene and Barry M. Brenner},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={71 1},
  pages={91-103}
}
A unilateral model of puromycin aminonucleoside (PAN)-induced albuminuria was produced in Munich-Wistar rats to examine the mechanisms responsible for renal salt retention. 2 wk after selective perfusion of left kidneys with PAN (n = 8 rats) or isotonic saline (control, n = 7 rats), increases in albumin excretion and decreases in sodium excretion were… CONTINUE READING