Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells.

@article{Krampera2006RoleFI,
  title={Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells.},
  author={Mauro Krampera and Lorenzo Cosmi and Roberta Angeli and Annalisa Pasini and F Leonarda Liotta and Angelo Andreini and Veronica Santarlasci and Benedetta Mazzinghi and Giovanni Pizzolo and Fabrizio Vinante and Paola Romagnani and Enrico Maggi and Sergio Romagnani and Francesco Annunziato},
  journal={Stem cells},
  year={2006},
  volume={24 2},
  pages={386-98}
}
Mesenchymal stem cells (MSCs) inhibit the proliferation of HLA-unrelated T lymphocytes to allogeneic stimulation, but the mechanisms responsible for this activity are not fully understood. We show here that MSCs suppress the proliferation of both CD4+ and CD8+ T lymphocytes, as well as of natural killer (NK) cells, whereas they do not have an effect on the proliferation of B lymphocytes. The antiproliferative effect of MSCs was not associated with any effect on the expression of cell-activation… CONTINUE READING
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