Role for influenza virus envelope cholesterol in virus entry and infection.

@article{Sun2003RoleFI,
  title={Role for influenza virus envelope cholesterol in virus entry and infection.},
  author={Xiangjie Sun and Gary R. Whittaker},
  journal={Journal of virology},
  year={2003},
  volume={77 23},
  pages={
          12543-51
        }
}
Enveloped viruses are highly dependent on their lipid envelopes for entry into and infection of host cells. Here, we have examined the role of cholesterol in the virus envelope, using methyl-beta-cyclodextrin depletion. Pretreatment of virions with methyl-beta-cyclodextrin efficiently depleted envelope cholesterol from influenza virus and significantly reduced virus infectivity in a dose-dependent manner. A nonenveloped virus, simian virus 40, was not affected by methyl-beta-cyclodextrin… CONTINUE READING

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