Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets

@inproceedings{Favre2011RoleFI,
  title={Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets},
  author={Dimitri Favre and Guy Niederhauser and Denis Fahmi and Val{\'e}rie Plaisance and Sa{\vs}ka Brajkovic and Nicole Beeler and Florent Allagnat and J. A. Haefliger and Romano Regazzi and G{\'e}rard Waeber and Amar Abderrahmani},
  booktitle={Diabetologia},
  year={2011}
}
Pro-atherogenic and pro-oxidant, oxidised LDL trigger adverse effects on pancreatic beta cells, possibly contributing to diabetes progression. Because oxidised LDL diminish the expression of genes regulated by the inducible cAMP early repressor (ICER), we investigated the involvement of this transcription factor and of oxidative stress in beta cell failure elicited by oxidised LDL. Isolated human and rat islets, and insulin-secreting cells were cultured with human native or oxidised LDL or with… CONTINUE READING

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multiple clinical applications

Millea PJ N-acetylcysteine
Am Fam Physician 80:265–269 2346 Diabetologia • 2011
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