Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.

  title={Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.},
  author={Benjamin Boutrel and Paul J. Kenny and Sheila E. Specio and R{\'e}mi Martin-Fardon and A. Markou and George F. Koob and Luis de Lecea},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 52},
Hypocretin-1 and -2 (Hcrt-1 and Hcrt-2), also referred to as orexin-A and -B, are neuropeptides synthesized by a few thousand neurons in the lateral hypothalamus. Hypocretin-containing neurons project throughout the brain, with a prominent input to basal forebrain structures involved in motivation, reward, and stress. However, the role of hypocretins in addiction-related behaviors remains largely unexplored. Here we show that intracerebroventricular infusions of Hcrt-1 lead to a dose-related… CONTINUE READING
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