Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization.

@article{Guyader2002RoleFH,
  title={Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization.},
  author={Mireille Guyader and Etsuko Kiyokawa and Laurence Abrami and Priscilla Turelli and Didier Trono},
  journal={Journal of virology},
  year={2002},
  volume={76 20},
  pages={10356-64}
}
The membrane of human immunodeficiency virus type 1 (HIV-1) virions contains high levels of cholesterol and sphingomyelin, an enrichment that is explained by the preferential budding of the virus through raft microdomains of the plasma membrane. Upon depletion of cholesterol from HIV-1 virions with methyl-beta-cyclodextrin, infectivity was almost completely abolished. In contrast, this treatment had only a mild effect on the infectiousness of particles pseudotyped with the G envelope of… CONTINUE READING

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