Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells.

@article{Rutella2002RoleFG,
  title={Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells.},
  author={Sergio Rutella and Luca Pierelli and Giuseppina Bonanno and Simona Sica and Franco Ameglio and Ettore Capoluongo and Andrea Mariotti and Giovanni Scambia and Giuseppe D'onofrio and Giuseppe Leone},
  journal={Blood},
  year={2002},
  volume={100 7},
  pages={2562-71}
}
Granulocyte colony-stimulating factor (G-CSF) may affect T-cell homeostasis by multiple mechanisms, inducing polarization of cytokine secretion, inhibition of T-cell proliferation, and enhancement of T-cell apoptosis. We analyzed the production of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) by T cells from healthy volunteer donors treated with recombinant human G-CSF. Highly purified CD4(+) T cells obtained before and after G-CSF administration (pre-G and post-G… CONTINUE READING

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