Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.

@article{Sonsalla1989RoleFE,
  title={Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.},
  author={Patricia K. Sonsalla and William J. Nicklas and Richard E. Heikkila},
  journal={Science},
  year={1989},
  volume={243 4889},
  pages={398-400}
}
The systemic administration of either methamphetamine or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to experimental animals produces degenerative changes in nigrostriatal dopaminergic neurons or their axon terminals. This study was conducted to determine if excitatory amino acids, which appear to be involved in various neurodegenerative disorders, might also contribute to the dopaminergic neurotoxicity produced in mice by either methamphetamine or MPTP. MK-801, phencyclidine, and… CONTINUE READING

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