Role for cyclin-dependent kinase 2 in mitosis exit

  title={Role for cyclin-dependent kinase 2 in mitosis exit},
  author={Vincenzo D'Angiolella and Vincenzo Costanzo and Max E. Gottesman and Enrico Vittorio Avvedimento and J -C. Gautier and Domenico Luca Grieco},
  journal={Current Biology},
Mitosis requires cyclin-dependent kinase (cdk) 1-cyclin B activity [1]. Exit from mitosis depends on the inactivation of the complex by the degradation of cyclin B [2]. Cdk2 is also active during mitosis [3, 4]. In Xenopus egg extracts, cdk2 is primarily in complex with cyclin E, which is stable [5]. At the end of mitosis, downregulation of cdk2-cyclin E activity is accompanied by inhibitory phosphorylation of cdk2 [6]. Here, we show that cdk2-cyclin E activity maintains cdk1-cyclin B during… CONTINUE READING