Role for complement in the development of seizures following acute viral infection.

  title={Role for complement in the development of seizures following acute viral infection.},
  author={Jane E. Libbey and Nikki J. Kirkman and Karen S. Wilcox and Henry S White and Robert Shin Fujinami},
  journal={Journal of virology},
  volume={84 13},
Complement, part of the innate immune system, acts to remove pathogens and unwanted host material. Complement is known to function in all tissues, including the central nervous system (CNS). In this study, we demonstrated the importance of the complement system within the CNS in the development of behavioral seizures following Theiler's murine encephalomyelitis virus (TMEV) infection. C57BL/6 mice, deficient in complement component C3, developed significantly fewer behavioral seizures following… CONTINUE READING


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