Role for complement in the development of seizures following acute viral infection.

@article{Libbey2010RoleFC,
  title={Role for complement in the development of seizures following acute viral infection.},
  author={Jane E. Libbey and Nikki J. Kirkman and Karen S. Wilcox and Henry S White and Robert Shin Fujinami},
  journal={Journal of virology},
  year={2010},
  volume={84 13},
  pages={6452-60}
}
Complement, part of the innate immune system, acts to remove pathogens and unwanted host material. Complement is known to function in all tissues, including the central nervous system (CNS). In this study, we demonstrated the importance of the complement system within the CNS in the development of behavioral seizures following Theiler's murine encephalomyelitis virus (TMEV) infection. C57BL/6 mice, deficient in complement component C3, developed significantly fewer behavioral seizures following… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Complement and viral pathogenesis.

View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 47 references

posting date. Theiler’s virus infection chronically alters seizure susceptibility

Stewart, A K.-A., K. S. Wilcox, R. S. Fujinami, H. S. White
Epilepsia [Epub ahead of print] • 2009
View 1 Excerpt

Possible role of the innate immunity in temporal lobe epilepsy

K. L. van Gassen, M. de Wit, +5 authors P. N. de Graan
Epilepsia • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…