Role for cathepsin K in emphysema in smoke-exposed guinea pigs.

  title={Role for cathepsin K in emphysema in smoke-exposed guinea pigs.},
  author={Polina Golovatch and Becky A Mercer and Vincent Lema{\^i}tre and Alison F Wallace and Robert F Foronjy and Jeanine M D'armiento},
  journal={Experimental lung research},
  volume={35 8},
The protease-antiprotease imbalance in the lung plays an important role in the pathogenesis of smoke-induced emphysema. The aim of this study was to characterize the proteolytic responses leading to emphysema formation in the guinea pig smoke exposure model. Guinea pigs were exposed to cigarette smoke for 1, 2, 4, 8, and 12 weeks. Age-matched guinea pigs exposed to room air served as controls. Cigarette smoke induced inflammation after 4 weeks and generated emphysematous changes in the guinea… CONTINUE READING
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