Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas.

Abstract

Immature T cells and some T cell hybridomas undergo apoptotic cell death when activated through the T cell receptor complex, a phenomenon that is probably related to antigen induced negative selection of developing T cells. This activation-induced apoptosis depends on active protein and RNA synthesis in the dying cells, although none of the genes required… (More)

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@article{Shi1992RoleFC, title={Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas.}, author={Yan Shi and Jason Glynn and Lydie Guilbert and Tom G Cotter and Rachel Bissonnette and D. R. Green}, journal={Science}, year={1992}, volume={257 5067}, pages={212-4} }