Role for c-Jun N-terminal kinase in beta-cell recovery from nitric oxide-mediated damage.

@article{Scarim2003RoleFC,
  title={Role for c-Jun N-terminal kinase in beta-cell recovery from nitric oxide-mediated damage.},
  author={Anna L. Scarim and Sheri Y Nishimoto and Sarah M. Weber and John A Corbett},
  journal={Endocrinology},
  year={2003},
  volume={144 8},
  pages={3415-22}
}
Treatment of rat islets with the cytokine IL-1 results in the inhibition of mitochondrial function and insulin secretion, events that are mediated by beta-cell expression of iNOS [inducible nitric oxide (NO) synthase] and production of NO. beta-Cells recover from the inhibitory actions of NO, produced following 24 h incubation with IL-1, on islet oxidative metabolism and insulin secretion if iNOS enzymatic activity is inhibited and the islets are cultured (in the presence of IL-1 and iNOS… CONTINUE READING
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