Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.

Abstract

The c-Abl protein tyrosine kinase is activated by certain DNA-damaging agents, and its overexpression causes arrest in the G1 phase of the cell cycle by a mechanism dependent on the tumour-suppressor protein p53 (refs 2-4). Here we investigate the possible role of c-Abl in growth arrest induced by DNA damage. Transient transfection experiments using wild… (More)

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Cite this paper

@article{Yuan1996RoleFC, title={Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.}, author={Z M Yuan and Yan Huang and Young E. Whang and Charles L Sawyers and Ralph R. Weichselbaum and Surender M. Kharbanda and Donald Kufe}, journal={Nature}, year={1996}, volume={382 6588}, pages={272-4} }