Role for astroglial α1-adrenoreceptors in gliotransmission and control of synaptic plasticity in the neocortex

@inproceedings{Pankratov2015RoleFA,
  title={Role for astroglial α1-adrenoreceptors in gliotransmission and control of synaptic plasticity in the neocortex},
  author={Yuriy Pankratov and Ulyana Lalo},
  booktitle={Front. Cell. Neurosci.},
  year={2015}
}
Communication between neuronal and glial cells is thought to be very important for many brain functions. Acting via release of gliotransmitters, astrocytes can modulate synaptic strength. The mechanisms underlying gliotransmission remain uncertain with exocytosis being the most intriguing and debated pathway. We demonstrate that astroglial α1-adrenoreceptors are very sensitive to noradrenaline (NA) and make a significant contribution to intracellular Ca(2+)-signaling in layer 2/3 neocortical… CONTINUE READING
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