Role for angiotensin II in an overt functional proteinuria.

@article{Yoshioka1986RoleFA,
  title={Role for angiotensin II in an overt functional proteinuria.},
  author={Tadao Yoshioka and Tetsuya Mitarai and Valentina Kon and William M. Deen and Helmut G. Rennke and Iekuni Ichikawa},
  journal={Kidney international},
  year={1986},
  volume={30 4},
  pages={538-45}
}
A partial renal vein constriction (RVC) was induced acutely in Munich-Wistar rats. RVC caused a marked reduction in glomerular plasma flow rate, and rises in glomerular transcapillary hydraulic pressure difference and efferent arteriolar resistance. These changes were associated with a marked increase in urinary protein excretion, on average from a baseline level of 8 to approximately 120 mg/24 hrs per kidney. Infusion of saralasin, an angiotensin II (AII) antagonist, largely normalized these… CONTINUE READING

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