Role for amplification and expression of glypican-5 in rhabdomyosarcoma.

  title={Role for amplification and expression of glypican-5 in rhabdomyosarcoma.},
  author={Daniel Williamson and Joanna L Selfe and Tony Gordon and Yong-Jie Lu and Kathy Pritchard-Jones and Kasumi Murai and P. C. T. Jones and Paul Workman and Janet Shipley},
  journal={Cancer research},
  volume={67 1},
Overexpression of genes, through genomic amplification and other mechanisms, can critically affect the behavior of tumor cells. Genomic amplification of the 13q31-32 region is reported in many tumors, including rhabdomyosarcomas that are primarily pediatric sarcomas resembling developing skeletal muscle. The minimum overlapping region of amplification at 13q31-32 in rhabdomyosarcomas was defined as containing two genes: Glypican-5 (GPC5) encoding a cell surface proteoglycan and C13orf25… CONTINUE READING


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