Role for a bidentate ribonuclease in the initiation step of RNA interference

@article{Bernstein2001RoleFA,
  title={Role for a bidentate ribonuclease in the initiation step of RNA interference},
  author={Emily Bernstein and Amy A. Caudy and Scott M. Hammond and Gregory J. Hannon},
  journal={Nature},
  year={2001},
  volume={409},
  pages={363-366}
}
RNA interference (RNAi) is the mechanism through which double-stranded RNAs silence cognate genes. In plants, this can occur at both the transcriptional and the post-transcriptional levels; however, in animals, only post-transcriptional RNAi has been reported to date. In both plants and animals, RNAi is characterized by the presence of RNAs of about 22 nucleotides in length that are homologous to the gene that is being suppressed. These 22-nucleotide sequences serve as guide sequences that… Expand
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