Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime

@article{Ko2002RoleFS,
  title={Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime},
  author={H. Ko and J. Jiang and I. Edery},
  journal={Nature},
  year={2002},
  volume={420},
  pages={673-678}
}
  • H. Ko, J. Jiang, I. Edery
  • Published 2002
  • Biology, Medicine
  • Nature
  • Protein phosphorylation has a key role in modulating the stabilities of circadian clock proteins in a manner specific to the time of day. A conserved feature of animal clocks is that Period (Per) proteins undergo daily rhythms in phosphorylation and levels, events that are crucial for normal clock progression. Casein kinase Iε (CKIε) has a prominent role in regulating the phosphorylation and abundance of Per proteins in animals. This was first shown in Drosophila with the characterization of… CONTINUE READING
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