Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
@article{Ko2002RoleFS, title={Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime}, author={H. Ko and J. Jiang and I. Edery}, journal={Nature}, year={2002}, volume={420}, pages={673-678} }
Protein phosphorylation has a key role in modulating the stabilities of circadian clock proteins in a manner specific to the time of day. A conserved feature of animal clocks is that Period (Per) proteins undergo daily rhythms in phosphorylation and levels, events that are crucial for normal clock progression. Casein kinase Iε (CKIε) has a prominent role in regulating the phosphorylation and abundance of Per proteins in animals. This was first shown in Drosophila with the characterization of… CONTINUE READING
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