Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts.

@article{Kumar2012RoleFR,
  title={Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts.},
  author={S. Kiran Kumar and Hae Yong Yoo and Akiko Kumagai and Anna Shevchenko and Andrej Shevchenko and William G. Dunphy},
  journal={Cell cycle},
  year={2012},
  volume={11 6},
  pages={1183-94}
}
TopBP1 is critical for both DNA replication and checkpoint regulation in vertebrate cells. In this study, we have identified Rif1 as a binding partner of TopBP1 in Xenopus egg extracts. In addition, Rif1 also interacts with both ATM and the Mre11-Rad50-Nbs1 (MRN) complex, which are key regulators of checkpoint responses to double-stranded DNA breaks (DSBs… CONTINUE READING