Role for Neuronal Nitric-Oxide Synthase in Cannabinoid-Induced Neurogenesis

  title={Role for Neuronal Nitric-Oxide Synthase in Cannabinoid-Induced Neurogenesis},
  author={Sun Hee Kim and Seok Joon Won and Xiao Ou Mao and Catherine Ledent and Kunlin Jin and David A. Greenberg},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={150 - 154}
  • S. H. KimS. Won D. Greenberg
  • Published 1 October 2006
  • Biology, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
Cannabinoids, acting through the CB1 cannabinoid receptor (CB1R), protect the brain against ischemia and related forms of injury. This may involve inhibiting the neurotoxicity of endogenous excitatory amino acids and downstream effectors, such as nitric oxide (NO). Cannabinoids also stimulate neurogenesis in the adult brain through activation of CB1R. Because NO has been implicated in neurogenesis, we investigated whether cannabinoid-induced neurogenesis, like cannabinoid neuroprotection, might… 

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