Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress.

@article{Kinoshita2014RoleFN,
  title={Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress.},
  author={Yayoi Kinoshita and Richard G. Hunter and Jason D. Gray and Roxana E Mesias and Bruce S. McEwen and Deanna L. Benson and D. Stave Kohtz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 45},
  pages={16130-5}
}
Genetic evidence suggests cell-type-specific functions for certain nucleoporins, and gene expression profiling has revealed that nucleoporin p62 (NUP62) transcripts are decreased in the prefrontal cortex of major depressives. Chronic stress, which can precipitate depression, induces changes in the architecture and plasticity of apical dendrites that are particularly evident in the CA3 region of the hippocampus. Genetically targeted translating ribosome affinity purification revealed a selective… CONTINUE READING
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