Role for Msh5 in the regulation of Ig class switch recombination.

@article{Sekine2007RoleFM,
  title={Role for Msh5 in the regulation of Ig class switch recombination.},
  author={Hideharu Sekine and Ricardo Cesar Alves Ferreira and Qiang Pan-Hammarstr{\"o}m and Robert R. Graham and Beth Ziemba and Sandra S de Vries and Jiabin Liu and Keli L Hippen and Thearith Koeuth and Ward Ortmann and Akiko Iwahori and Margaret K. Elliott and Steven M. Offer and Cara Noelle Skon and Likun Du and Jill M Novitzke and Annette T. Lee and Nianxi Zhao and Joshua D. Tompkins and David Altshuler and Peter K. Gregersen and Charlotte Cunningham-Rundles and Reuben S Harris and Chengtao Her and David L. G. Nelson and Lennart Hammarstr{\"o}m and Gary S. Gilkeson and Timothy W. Behrens},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 17},
  pages={
          7193-8
        }
}
Ig class switch recombination (CSR) and somatic hypermutation serve to diversify antibody responses and are orchestrated by the activity of activation-induced cytidine deaminase and many proteins involved in DNA repair and genome surveillance. Msh5, a gene encoded in the central MHC class III region, and its obligate heterodimerization partner Msh4 have a critical role in regulating meiotic homologous recombination and have not been implicated in CSR. Here, we show that MRL/lpr mice carrying a… CONTINUE READING
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