Role for IgE in airway secretions: IgE immune complexes are more potent inducers than antigen alone of airway inflammation in a murine model.

@article{Zuberi2000RoleFI,
  title={Role for IgE in airway secretions: IgE immune complexes are more potent inducers than antigen alone of airway inflammation in a murine model.},
  author={Riaz I. Zuberi and John R. Apgar and Steve S. Chen and F T Liu},
  journal={Journal of immunology},
  year={2000},
  volume={164 5},
  pages={2667-73}
}
IgE is present in airway secretions from human patients with allergic rhinitis and bronchial asthma. However, the contribution of IgE present locally to the overall airway inflammation is not well understood. We hypothesize that Ag-specific IgE can capture airborne Ags and form immune complexes. These immune complexes may function as potent inducers of immune responses in the lung, contributing to the perpetuation of airway inflammation. BALB/c mice were first sensitized with OVA in alum… CONTINUE READING

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