Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions.

@article{Gottardi2004RoleFI,
  title={Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions.},
  author={Cara J Gottardi and Barry Gumbiner},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={286 4},
  pages={C747-56}
}
Inhibitor of beta-catenin and TCF-4 (ICAT) is a 9-kDa polypeptide that inhibits beta-catenin nuclear signaling by binding beta-catenin and competing its interaction with the transcription factor TCF (T cell factor), but basic characterization of the endogenous protein and degree to which it alters other beta-catenin functions is less well understood. At the subcellular level, we show that ICAT localizes to both cytoplasmic and nuclear compartments. In intestinal tissue, ICAT is upregulated in… CONTINUE READING
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