Role for EPS8 in squamous carcinogenesis.

  title={Role for EPS8 in squamous carcinogenesis.},
  author={Huixin Wang and Vyomesh Patel and Hiroshi Miyazaki and J. Silvio Gutkind and W A Yeudall},
  volume={30 1},
We have investigated the role of the signaling intermediate, EPS8, in tumor progression using a model system and in vivo. HN4 primary tumor cells express low levels of EPS8, similar to normal keratinocytes, and show minimal invasion in vitro in response to epidermal growth factor, whereas HN12 cells express high levels of EPS8 and are highly motile in vitro and tumorigenic in vivo. Additional independent tumor cell lines also showed elevated EPS8 expression compared with normal keratinocytes… CONTINUE READING
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