Role for DNA methylation in genomic imprinting

@article{Li1993RoleFD,
  title={Role for DNA methylation in genomic imprinting},
  author={E. Li and C. Beard and R. Jaenisch},
  journal={Nature},
  year={1993},
  volume={366},
  pages={362-365}
}
THE paternal and maternal genomes are not equivalent and both are required for mammalian development1,2. The difference between the parental genomes is believed to be due to gamete-specific differential modification, a process known as genomic imprinting. The study of transgene methylation has shown that methylation patterns can be inherited in a parent-of-origin-specific manner3–7, suggesting that DNA methylation may play a role in genomic imprinting. The functional significance of DNA… Expand
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