Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver.

@article{Sato2005RoleFC,
  title={Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver.},
  author={Tohru Sato and Henrik Thorlacius and Brent Johnston and Tracy L. Staton and Wenkai Xiang and Dan R. Littman and Eugene C. Butcher},
  journal={Journal of immunology},
  year={2005},
  volume={174 1},
  pages={
          277-83
        }
}
Hepatic infiltration of activated CD8 lymphocytes is a major feature of graft-vs-host disease (GvHD). Chemoattractant cytokines and their receptors are key regulators of lymphocyte trafficking, but the involvement of chemoattractant receptors in the physiologic recruitment of cells into the inflamed liver has not been defined. The present study examines the role of the chemokine receptor CXCR6, which is highly expressed by liver-infiltrating CD8 T cells. Hepatic accumulation of donor CD8, but… CONTINUE READING

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