Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.

Abstract

Most T lymphocytes are generated within the thymus. It is unclear, however, how newly generated T cells relocate out of the thymus to the circulation. The present study shows that a CC chemokine CCL19 attracts mature T cells out of the fetal thymus organ culture. Another CC chemokine CCL21, which shares CCR7 with CCL19 but has a unique C-terminal extension containing positively charged amino acids, failed to show involvement in thymic emigration. Neonatal appearance of circulating T cells was defective in CCL19-neutralized mice as well as in CCR7-deficient mice but not in CCL21-neutralized mice. In the thymus, CCL19 is predominantly localized in the medulla including endothelial venules. These results indicate a CCL19- and CCR7-dependent pathway of thymic emigration, which represents a major pathway of neonatal T cell export.

0100200'03'05'07'09'11'13'15'17
Citations per Year

969 Citations

Semantic Scholar estimates that this publication has 969 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Ueno2002RoleFC, title={Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.}, author={Tomoo Ueno and Kyoko Hara and Melissa Swope Willis and Mark A. Malin and Uta E. H{\"{o}pken and Andreas Strasser and Kouji Matsushima and Martin Lipp and Timothy A Springer and Richard L. Boyd and Osamu Yoshie and Yousuke Takahama}, journal={Immunity}, year={2002}, volume={16 2}, pages={205-18} }