Role and regulation of sperm gelsolin prior to fertilization.

  title={Role and regulation of sperm gelsolin prior to fertilization.},
  author={Maya Finkelstein and Nir Etkovitz and Haim Breitbart},
  journal={The Journal of biological chemistry},
  volume={285 51},
To acquire fertilization competence, spermatozoa should undergo several biochemical changes in the female reproductive tract, known as capacitation. The capacitated spermatozoon can interact with the egg zona pellucida resulting in the occurrence of the acrosome reaction, a process that allowed its penetration into the egg and fertilization. Sperm capacitation requires actin polymerization, whereas F-actin must disperse prior to the acrosome reaction. Here, we suggest that the actin-severing… CONTINUE READING