Role and regulation of interleukin (IL)-2 receptor alpha and beta chains in IL-2-driven B-cell growth.

@article{Nakanishi1992RoleAR,
  title={Role and regulation of interleukin (IL)-2 receptor alpha and beta chains in IL-2-driven B-cell growth.},
  author={Kazushige Nakanishi and Shinichi Hirose and Takayuki Yoshimoto and Hiromichi Ishizashi and Kazumasa Hiroishi and Toshitaka Tanaka and Takeshi Kono and Masayuki Miyasaka and T. Taniguchi and Kazuya Higashino},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 8},
  pages={3551-5}
}
Substantial proportions of resting B cells constitutively express low levels of IL-2 receptor (IL-2R) alpha and/or beta chains. The expression of these chains is differentially regulated by anti-IgM and IL-2/IL-4. The anti-IgM induces IL-2R alpha chain expression, whereas each of the two cytokines induces IL-2R beta chain expression in a dose-dependent manner. Moreover, IL-2 induces the growth of B cells, when the cells were pretreated with IL-2 or IL-4 for 24 h. The magnitude of this IL-2… CONTINUE READING

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