Role and regulation of autophagy in cancer.

  title={Role and regulation of autophagy in cancer.},
  author={Ning Chen and Vassiliki Karantza-Wadsworth},
  journal={Biochimica et biophysica acta},
  volume={1793 9},
Autophagy is an evolutionarily conserved process whereby cytoplasm and cellular organelles are degraded in lysosomes for amino acid and energy recycling. Autophagy is a survival pathway activated in response to nutrient deprivation and other stressful stimuli, such as metabolic stress and exposure to anticancer drugs. However, autophagy may also result in cell death, if it proceeds to completion. Defective autophagy is implicated in tumorigenesis, as the essential autophagy regulator beclin 1… CONTINUE READING


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  • D. Crighton, S. Wilkinson, +7 authors K. M. Ryan
  • a p53-induced modulator of autophagy, is critical…
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