Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells.

@article{Sakaguchi2012RoleAR,
  title={Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells.},
  author={Masanobu Sakaguchi and Masahiro Oka and Tetsushi Iwasaki and Yasuo Fukami and Chikako Nishigori},
  journal={The Journal of investigative dermatology},
  year={2012},
  volume={132 7},
  pages={1877-85}
}
The transcription factor signal transducer and activator of transcription 3 (STAT3) has two important phosphorylation sites, Tyr705 and Ser727, for its activation. Ser727 phosphorylation has been considered to be a secondary event after Tyr705 phosphorylation. In this study, the role and regulation of Ser727 phosphorylation in STAT3 in melanocytic cells were examined. STAT3 was phosphorylated on Ser727 in the absence of Tyr705 phosphorylation in melanocytes. 12-O-tetradecanoylphorbol-13-acetate… CONTINUE READING
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