Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

  title={Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.},
  author={Morten Fr{\"o}din and Steen Gammeltoft},
  journal={Molecular and cellular endocrinology},
  volume={151 1-2},
Extracellular signals activate mitogen-activated protein kinase (MAPK) cascades to execute complex cellular programs, like proliferation, differentiation and apoptosis. In mammalian cells, three MAPK families have been characterized: extracellular signal-regulated kinase (ERK), which is activated by growth factors, peptide hormones and neurotransmitters, and Jun kinase (JNK) and p38 MAPK, which are activated by cellular stress stimulus as well as growth factors. This review describes the family… CONTINUE READING
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