Role and prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand death receptor DR5 in nonsmall-cell lung cancer and precursor lesions.

@article{Cooper2008RoleAP,
  title={Role and prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand death receptor DR5 in nonsmall-cell lung cancer and precursor lesions.},
  author={Wendy A. Cooper and Maija R J Kohonen-Corish and Liqing Zhuang and Brian C. McCaughan and Catherine W Kennedy and Gavin Robert Screaton and Robert Lyndsay Sutherland and C V Lee},
  journal={Cancer},
  year={2008},
  volume={113 1},
  pages={135-42}
}
BACKGROUND The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor, DR5, mediates proapoptotic signals and is implicated in the pathogenesis of many neoplasms including nonsmall-cell lung cancer (NSCLC). METHODS In this study, immunohistochemical expression of DR5 was examined in 146 cases of stage I and II NSCLC as well as neoplastic precursor lesions and regional lymph node metastases using tissue microarrays. RESULTS High DR5 expression was observed in 67.1% of… CONTINUE READING