Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

@article{Zhu2019RoleAM,
  title={Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage},
  author={Huimin Zhu and Zhiqiang Wang and Jixu Yu and Xiuli Yang and Feng He and Zhenchuan Liu and Fengyuan Che and Xuemei Chen and Honglei Ren and Michael Hong and Jian Wang},
  journal={Progress in Neurobiology},
  year={2019},
  volume={178}
}
Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage
TLDR
Some key pathophysiology mechanisms in ICH such as oxidative stress, inflammation, iron toxicity, and thrombin formation are discussed and the corresponding therapeutic targets and therapeutic strategies are reviewed.
Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update
  • Honglei Ren, R. Han, Jian Wang
  • Biology, Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2020
TLDR
An update of recent progress on ICH is provided and the prospects for further preclinical studies in this field are described and new therapeutic targets and directions for the treatment of ICH are discussed.
Microglia Phenotype and Intracerebral Hemorrhage: A Balance of Yin and Yang
TLDR
The dual functions of microglia in the brain after an ICH from immunological perspective are discussed, the activation mechanism of perihematomalmicroglia is elaborate, and related therapeutic drugs researches are summarized.
Raddeanin A (RA) reduced acute inflammatory injury in mouse experimental cerebral hemorrhage by suppression of TLR4
TLDR
RA can alleviate ICH-related tissue damage and promote the recovery of neuronal function by suppressing microglia-induced inflammation and apoptosis and downregulated the TLR4-mediated pro-inflammatory effectors.
Mechanism of White Matter Injury and Promising Therapeutic Strategies of MSCs After Intracerebral Hemorrhage
TLDR
The characteristics of WMI following ICH are discussed, including the mechanism and potential promising therapeutic targets of MSCs, aiming at providing new clues for future therapeutic strategies.
Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage
TLDR
This review summarizes recent progress of the mechanisms by which deferoxamine may alleviate ICH and discusses further studies on its clinical utility.
Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage
TLDR
This review summarizes the efficacy of several Nrf2 activators in ICH animal models and suggests that in the future, Nrf 2 activators might be approved for the treatment of ICH patients.
Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update
TLDR
The treatment of intracerebral hemorrhage using stem cells and exosomes from both preclinical and clinical studies is reviewed and the possible mechanisms of stem cell therapy are summarized to provide a reference for future research and new strategies for clinical treatment.
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References

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Some promising advances in the field of inflammation and ICH are summarized, which contained animal and human investigations; discussed the role of neuroinflammation, systemic inflammatory responses, and some potential targets; and focused on the challenges of translation between pre-clinical and clinical studies and potential anti-inflammatory therapeutic approaches after ICH.
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In this review, a summary of the available literature on the inflammatory responses after ICH is presented along with discussion of some of the emerging opportunities for potential therapeutic strategies.
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