Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets.

@article{Tian2006RoleAM,
  title={Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets.},
  author={Jing-yan Tian and Guo Li and Yan-yun Gu and Hong-li Zhang and Wen-zhong Zhou and Xiao Lou Wang and Hong-da Zhu and Tian-hong Luo and Min Luo},
  journal={Chinese medical journal},
  year={2006},
  volume={119 7},
  pages={574-80}
}
BACKGROUND Prolonged exposure of pancreatic beta-cells to fatty acids increases basal insulin secretion but inhibits glucose-stimulated insulin secretion. Rosiglitazone is a new antidiabetic agent of the thiazolidinediones. However, the relationship between thiazolidinediones and insulin secretion is highly controversial. The aim of this study is to explore the effect and mechanism of rosiglitazone on insulin secretion of islets under chronic exposure to free fatty acids (FFA). METHODS… CONTINUE READING
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