Role and interpretation of total serum IgE measurements in the diagnosis of allergic airway disease in adults

@article{Kerkhof2003RoleAI,
  title={Role and interpretation of total serum IgE measurements in the diagnosis of allergic airway disease in adults},
  author={Marjan Kerkhof and A E J Dubois and Dirkje S Postma and Jan Peter Schouten and J. G. R. Monchy},
  journal={Allergy},
  year={2003},
  volume={58}
}
Background: While total IgE measurements are often used in clinical practice, it is unclear how they should be interpreted for the diagnosis of allergic disorders. We studied whether total IgE may be used to rule out or predict sensitization and whether there are age or gender differences. 
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85 Citations
Highly Influential Citations
2
Background Citations
26
Methods Citations
3
Results Citations
3

85 Citations

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The value of total IgE levels in the context of specific allergy

  • S. KhanP. DoréW. Sewell
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    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2008
The authors mention that in 22% of cases the clinician remained uncertain of the diagnosis even after the specific IgE results were available, which could mean that the lack of a total IgE was one of the reasons why appropriate comments were not appended to the results during laboratory validation.

Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I

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Rationale for specific allergen testing of patients with asthma in the clinical pulmonary office setting.

The importance of allergen testing in patients with asthma—whether by skin testing or by in vitro methods—is reviewed and the advantages, limitations, and interpretation of results derived from each method are highlighted.

Elevated total serum immunoglobulin E (>1000 IU/mL): implications?

Of 352 patients with IgE >1000 IU/mL seen in the authors' hospital over a 5‐year period, less than 50% had these conditions, andedly elevated IgE levels in the rest of the patients were associated with asthma, allergic rhinitis and food allergy, instances where the test is of limited diagnostic utility.
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References

SHOWING 1-10 OF 17 REFERENCES

Serum total immunoglobulin E levels in Canadian adults.

[Visagnost--a strip test for in vitro allergy diagnosis in comparison with Magic Lite and Cap-FEIA: I. Total IgE determination].

  • G. Rasp
  • Medicine
    Laryngo- rhino- otologie
  • 1992
A recently developed dipstick test for allergy screening now enables every practitioner to determine total IgE levels within less than one hour, and gives results in four ranges of minor to major allergy, as shown for semiquantitative glucose dipsticks.

Age-related serum immunoglobulin E levels in healthy subjects and in patients with allergic disease.

Total Serum IgE Concentrations in Adolescents and Adults Using the Phadebas IgE PRIST® Technique

Asthmatic patients had higher mean IgE levels than those who were suffering from either rhinitis or conjunctivitis, and this suggests that the mean total serum IgE concentration is remarkably constant in normal non‐allergic Caucasians.

The use of Phadiatop® in mass‐screening programmes of inhalant allergies: advantages and limitations

As the high percentage of cases in the unselected population had specific serum IgE against inhalant allergens and no allergic symptomatology, the Phadialop‐positive predictive value falls to 53.7%, thus creating the need for Phadiatop‐ positive subjects to undergo further investigation for an appropriate diagnosis.

Evaluation of the Phadiatop® test in an epidemiological study

It is concluded that the Phadiatop is a valuable test for the screening of inhalant atopy, and as the percentage binding may reflect the degree of sensitization it could also be applied as a quantitative measure especially for epidemiological purposes.

Visagnost - ein Streifentest zur In-Vitro-Allergie-Diagnostik im Vergleich mit Magic Lite und Cap-FEIA - Teil 1: Gesamt-IgE-Bestimmung

A recently developed dipstick test for allergy screening now enables every practitioner to determine total IgE levels within less than one hour, and gives results in four ranges of minor to major allergy, as shown for semiquantitative glucose dipsticks.

Serum total IgE levels in a representative sample of a Greek population

The comparison of normal IgE values (nonatopic subjects) from this study with those reported by other investigators revealed that Greek adult males and females had higher IgE levels than populations from other nations.

Problems in defining normal limits for serum IgE.

Levels of IgE in serum from normal children and allergic children as measured by an enzyme immunoassay.