Role and control of isocitrate lyase in Candida lipolytica.

@article{Matsuoka1980RoleAC,
  title={Role and control of isocitrate lyase in Candida lipolytica.},
  author={Makoto Matsuoka and Yoshinami Ueda and Shuichi Aiba},
  journal={Journal of bacteriology},
  year={1980},
  volume={144 2},
  pages={
          692-7
        }
}
Mutants of Candida lipolytica that were unable to grow on acetate but able to utilize succinate or glycerol as a sole carbon source were isolated. Amongst the mutants isolated, one strain (Icl-) was specifically deficient in isocitrate lyase activity, whereas another strain (Acos-) was deficient in acetyl coenzyme A synthetase activity. Since the Icl- mutant could not grow either on n-alkane or its derivatives, such as fatty acid and long-chain dicarboxylic acid, any anaplerotic route other… CONTINUE READING

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