Roflumilast reverses polymicrobial sepsis-induced liver damage by inhibiting inflammation in mice.

Abstract

Sepsis is a life-threatening syndrome accompanied by an overwhelming inflammatory response and organ dysfunction. Selective targeting of phosphodiesterase 4 (PDE4) is currently being investigated as an effective therapeutic approach for inflammation-associated diseases. Roflumilast is a selective PDE4 inhibitor, used for the treatment of severe chronic… (More)
DOI: 10.1038/labinvest.2017.59

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